Thyroid cancer and disorder are one of the leading endocrine disorders which affects approximately 4.2 crore people of India. Inspite of the large population affected from this disease, still at present there is no database that catalogues genes involved in thyroid cancer and disorder. As a result, it has become canonical to develop a specific database that would help in understanding the genes that regulate the proliferation of thyroid cancer and diseases. Each entry contains information regarding the gene and protein sequences, its gene symbol, gene id, accession number, protein name, chromosomal location, location in cell, pathway and comments. In addition we provide rich cross reference to other web resources like Uniprot, HPRD, HGNC, Ensemble and OMIM augmenting TCGDB-specific information with external data. TCGDB also provides relevant literature references of genes included in the database.