DBDiaSNP

   Diarrhea remains one of the leading causes of morbidity and mortality among children under 5 years of age and is associated with impaired physical and cognitive development in resource-limited countries. Why is Diarrhea, considered as an easily preventable and treatable disease, causing an estimated 1.5 million under-five deaths every year? There are number of pathogens involved in Diarrhea (for example; E.coli, Shigella, Rotavirus, campylobacter etc.)

   Significant portion of genetic polymorphisms in the host and pathogen genome affect the drug response by changing protein structure. It is crucial to understand this bilateral relationship between Diarrhea and Genome Variations. A database of the variations and resistance genes in a group of organisms is not only useful for understanding genotype-phenotype relationship but also in clinical applications.

   DBDiaSNP is an integrated web-based resource that provides a comprehensive listing of genetic variations and resistance genes associated with drug resistance among clinical isolates of Diarrheal pathogens and hosts throughout the world. It houses SNP data from published literature and manually curated from different web resources with an intuitive search tool. We hope it will advance breaktroughs in the field of Diarrheal diseases.